Science-Class.net is a great science resource my wife found for me. She teaches high school Biology and was using it with her class. Even though it is listed as being for elementary and middle school science educators, there are great resources that can be used with high school and there are some that are categorized as high school.
The site has resources divided by topic area: astronomy, biology, chemistry, forensics, physics, and much more. There are also teacher resources like graphic organizers and lesson plans. The student resource section has study skills and other web resources. There is even a section with parent resources.
Each topic area has a variety of links and resources such as activities, labs, slideshows, graphic organizers, online quizzes, study and review notes, and much more. The resources are categorized nicely and are very good.
Science-Class.net is a great resource for all science educators and students.